Drug interactions
Amisulpride + Propofol
Severity: Moderate
Amisulpride and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amisulpride can add to the sedation and hypotension produced by propofol. Both drugs may also affect QT interval in a clinical setting, though propofol itself is not a major QT risk.
What this interaction means in plain words
Amisulpride and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension from dopamine antagonism combined with GABAergic anesthesia.
What to do
Titrate propofol cautiously and monitor sedation, blood pressure and ECG, especially if other QT-prolonging drugs or electrolyte disturbances are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Frequently asked questions
Can I take Amisulpride with Propofol?
MediHelp rates the interaction as moderate. Amisulpride and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amisulpride can add to the sedation and hypotension produced by propofol. Both drugs may also affect QT interval in a clinical setting, though propofol itself is not a major QT risk.
How serious is the interaction between Amisulpride and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor sedation, blood pressure and ECG, especially if other QT-prolonging drugs or electrolyte disturbances are present.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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