Drug interactions
Amlodipine-atorvastatin + Silodosin
Severity: Moderate
Amlodipine-atorvastatin and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, which may add to the effect of amlodipine. Dizziness and syncope are most likely when starting therapy.
What this interaction means in plain words
Amlodipine-atorvastatin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-atorvastatin belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive hypotensive effects of alpha-1A adrenergic blockade and calcium channel blockade.
What to do
Monitor blood pressure, including orthostatic readings, when silodosin is started in patients on amlodipine. Advise slow position changes and reduce the antihypertensive dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-atorvastatin
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Amlodipine-atorvastatin with Silodosin?
MediHelp rates the interaction as moderate. Amlodipine-atorvastatin and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin is an alpha-1A blocker that can cause orthostatic hypotension, which may add to the effect of amlodipine. Dizziness and syncope are most likely when starting therapy.
How serious is the interaction between Amlodipine-atorvastatin and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, including orthostatic readings, when silodosin is started in patients on amlodipine. Advise slow position changes and reduce the antihypertensive dose if symptoms occur.
What other medicines interact with Amlodipine-atorvastatin?
MediHelp also lists interactions of Amlodipine-atorvastatin with, for example, Amifostine, Apalutamide, Atazanavir. The full list is on the Amlodipine-atorvastatin page.
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