Drug interactions
Amlodipine-perindopril + Avanafil
Severity: Moderate
Amlodipine-perindopril and Avanafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Avanafil is a vasodilator that can add to the hypotensive effect of amlodipine and perindopril. Symptomatic hypotension, dizziness or syncope may occur.
What this interaction means in plain words
Amlodipine-perindopril and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Avanafil belongs to Genitourinary.
Why it happens
Additive vasodilation from PDE5 inhibition, calcium channel blockade and ACE inhibition.
What to do
Use the lowest avanafil dose first and monitor blood pressure and symptoms of hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Avanafil?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Avanafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Avanafil is a vasodilator that can add to the hypotensive effect of amlodipine and perindopril. Symptomatic hypotension, dizziness or syncope may occur.
How serious is the interaction between Amlodipine-perindopril and Avanafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest avanafil dose first and monitor blood pressure and symptoms of hypotension.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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