Drug interactions
Amlodipine-perindopril + Chlorpromazine
Severity: Moderate
Amlodipine-perindopril and Chlorpromazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine has alpha-blocking activity and can cause orthostatic hypotension, which may add to the blood-pressure lowering of amlodipine and perindopril. Elderly patients are at greater risk of falls.
What this interaction means in plain words
Amlodipine-perindopril and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-perindopril belongs to Cardiovascular; Chlorpromazine belongs to Central Nervous System.
Why it happens
Additive hypotension from alpha-adrenergic blockade combined with vasodilation and ACE inhibition.
What to do
Monitor blood pressure, especially on standing, when starting or increasing chlorpromazine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Amlodipine-perindopril with Chlorpromazine?
MediHelp rates the interaction as moderate. Amlodipine-perindopril and Chlorpromazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine has alpha-blocking activity and can cause orthostatic hypotension, which may add to the blood-pressure lowering of amlodipine and perindopril. Elderly patients are at greater risk of falls.
How serious is the interaction between Amlodipine-perindopril and Chlorpromazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially on standing, when starting or increasing chlorpromazine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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