Drug interactions
Amlodipine-perindopril + Prochlorperazine
Severity: Minor
Amlodipine-perindopril and Prochlorperazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine has alpha-blocking properties that may add to antihypertensive effects. Orthostatic hypotension and dizziness may occur, particularly in older patients.
What this interaction means in plain words
Amlodipine-perindopril and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amlodipine-perindopril belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive hypotensive effect from phenothiazine alpha-1 adrenergic blockade.
What to do
Monitor blood pressure and advise patients to rise slowly; adjust antihypertensive doses if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amlodipine-perindopril
- Aliskiren + Amlodipine-perindopril Contraindicated
- Amlodipine-perindopril + Protein a column Contraindicated
- Amlodipine-perindopril + Sacubitril / valsartan Contraindicated
- Amifostine + Amlodipine-perindopril Major
- Amiloride + Amlodipine-perindopril Major
- Amlodipine-perindopril + Azilsartan Major
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Amlodipine-perindopril with Prochlorperazine?
MediHelp rates the interaction as minor. Amlodipine-perindopril and Prochlorperazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prochlorperazine has alpha-blocking properties that may add to antihypertensive effects. Orthostatic hypotension and dizziness may occur, particularly in older patients.
How serious is the interaction between Amlodipine-perindopril and Prochlorperazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise patients to rise slowly; adjust antihypertensive doses if symptomatic.
What other medicines interact with Amlodipine-perindopril?
MediHelp also lists interactions of Amlodipine-perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Amlodipine-perindopril page.
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