Drug interactions
Amphetamine + Sodium zirconium cyclosilicate
Severity: Minor
Amphetamine and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can raise gastric pH transiently, which may change the dissolution of pH-dependent oral drugs, including some modified-release amphetamine products. Clinical significance for amphetamine is uncertain but could alter exposure or release profile.
What this interaction means in plain words
Amphetamine and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Amphetamine belongs to Central Nervous System; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may alter dissolution and release of pH-dependent oral formulations.
What to do
Give oral amphetamine at least 2 hours before or after sodium zirconium cyclosilicate, and monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Amphetamine
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Amphetamine with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Amphetamine and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can raise gastric pH transiently, which may change the dissolution of pH-dependent oral drugs, including some modified-release amphetamine products. Clinical significance for amphetamine is uncertain but could alter exposure or release profile.
How serious is the interaction between Amphetamine and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral amphetamine at least 2 hours before or after sodium zirconium cyclosilicate, and monitor clinical response.
What other medicines interact with Amphetamine?
MediHelp also lists interactions of Amphetamine with, for example, Iobenguane i, Ozanimod, Benzhydrocodone / acetaminophen. The full list is on the Amphetamine page.
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