Drug interactions
Apalutamide + Fenofibrate
Severity: Minor
Apalutamide and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenofibrate is not meaningfully metabolized by CYP3A4; it is hydrolyzed to fenofibric acid and cleared mainly by glucuronidation. A clinically significant interaction with the CYP3A4 inducer apalutamide is therefore not expected.
What this interaction means in plain words
Apalutamide and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Apalutamide belongs to Endocrine; Fenofibrate belongs to Cardiovascular.
Why it happens
Apalutamide induces CYP3A4 and UGTs, but fenofibric acid is cleared mainly by glucuronidation, so any effect is uncertain and probably small.
What to do
No dose change is needed; monitor the lipid profile as part of routine care after starting apalutamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Fenofibrate?
MediHelp rates the interaction as minor. Apalutamide and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenofibrate is not meaningfully metabolized by CYP3A4; it is hydrolyzed to fenofibric acid and cleared mainly by glucuronidation. A clinically significant interaction with the CYP3A4 inducer apalutamide is therefore not expected.
How serious is the interaction between Apalutamide and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor the lipid profile as part of routine care after starting apalutamide.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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