Drug interactions
Avanafil + Tucatinib
Severity: Moderate
Avanafil and Tucatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits CYP3A and may increase avanafil exposure. This may increase hypotension, visual effects and priapism.
What this interaction means in plain words
Avanafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avanafil belongs to Genitourinary; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits CYP3A4, reducing avanafil metabolism.
What to do
Use the lowest effective avanafil dose, within labeled limits for moderate CYP3A inhibitors, and monitor blood pressure and adverse effects. Consider an alternative agent if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Avanafil with Tucatinib?
MediHelp rates the interaction as moderate. Avanafil and Tucatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tucatinib inhibits CYP3A and may increase avanafil exposure. This may increase hypotension, visual effects and priapism.
How serious is the interaction between Avanafil and Tucatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective avanafil dose, within labeled limits for moderate CYP3A inhibitors, and monitor blood pressure and adverse effects. Consider an alternative agent if possible.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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