Drug interactions
Calcifediol + Enzalutamide
Severity: Minor
Calcifediol and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is a strong CYP3A4 inducer and may accelerate the hydroxylation and clearance of calcifediol. Serum 25-hydroxyvitamin D levels may fall and the intended effect on calcium and bone metabolism may be reduced.
What this interaction means in plain words
Calcifediol and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcifediol belongs to Musculoskeletal; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4-mediated catabolism of calcifediol, shortening its half-life.
What to do
Monitor serum 25-hydroxyvitamin D, calcium and PTH during long-term co-therapy. Increase the calcifediol dose if levels or clinical response are inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Enzalutamide?
MediHelp rates the interaction as minor. Calcifediol and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Enzalutamide is a strong CYP3A4 inducer and may accelerate the hydroxylation and clearance of calcifediol. Serum 25-hydroxyvitamin D levels may fall and the intended effect on calcium and bone metabolism may be reduced.
How serious is the interaction between Calcifediol and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, calcium and PTH during long-term co-therapy. Increase the calcifediol dose if levels or clinical response are inadequate.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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