Drug interactions
Calcifediol + Posaconazole
Severity: Moderate
Calcifediol and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Strong CYP inhibitors may alter vitamin D metabolism, changing calcifediol levels and limiting its conversion to active calcitriol. This could affect mineral balance and parathyroid hormone control.
What this interaction means in plain words
Calcifediol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcifediol belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP enzymes involved in vitamin D hydroxylation and catabolism, altering calcifediol and calcitriol formation.
What to do
Monitor serum 25-hydroxyvitamin D, intact PTH and calcium when posaconazole is started or stopped. Adjust the calcifediol dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Calcifediol
- Amlodipine-hydrochlorothiazide-valsartan + Calcifediol Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Calcifediol Moderate
- Amobarbital + Calcifediol Moderate
- Atenolol-chlorthalidone + Calcifediol Moderate
- Azilsartan-chlorthalidone + Calcifediol Moderate
- Calcifediol + Candesartan-hydrochlorothiazide Moderate
Frequently asked questions
Can I take Calcifediol with Posaconazole?
MediHelp rates the interaction as moderate. Calcifediol and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Strong CYP inhibitors may alter vitamin D metabolism, changing calcifediol levels and limiting its conversion to active calcitriol. This could affect mineral balance and parathyroid hormone control.
How serious is the interaction between Calcifediol and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum 25-hydroxyvitamin D, intact PTH and calcium when posaconazole is started or stopped. Adjust the calcifediol dose according to results.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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