Drug interactions
Chloroquine + Givosiran
Severity: Minor
Chloroquine and Givosiran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can inhibit CYP2D6 and may raise concentrations of CYP2D6 substrates such as chloroquine. The clinical effect on chloroquine is likely modest.
What this interaction means in plain words
Chloroquine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chloroquine belongs to Anti Parasitic; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP2D6 activity, decreasing chloroquine metabolism.
What to do
Monitor for chloroquine adverse effects; no routine dose adjustment is required for standard courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Chloroquine with Givosiran?
MediHelp rates the interaction as minor. Chloroquine and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can inhibit CYP2D6 and may raise concentrations of CYP2D6 substrates such as chloroquine. The clinical effect on chloroquine is likely modest.
How serious is the interaction between Chloroquine and Givosiran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for chloroquine adverse effects; no routine dose adjustment is required for standard courses.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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