Drug interactions
Chlorpromazine + Leuprolide
Severity: Moderate
Chlorpromazine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation with leuprolide may prolong the QT interval. Combined with chlorpromazine, which also prolongs QT, the risk of torsades de pointes may increase in patients with other risk factors.
What this interaction means in plain words
Chlorpromazine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive QT prolongation from androgen deprivation and phenothiazine effects.
What to do
Obtain a baseline ECG and monitor QTc periodically, correcting potassium and magnesium. Consider alternatives in patients with congenital long QT or significant cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Chlorpromazine with Leuprolide?
MediHelp rates the interaction as moderate. Chlorpromazine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation with leuprolide may prolong the QT interval. Combined with chlorpromazine, which also prolongs QT, the risk of torsades de pointes may increase in patients with other risk factors.
How serious is the interaction between Chlorpromazine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically, correcting potassium and magnesium. Consider alternatives in patients with congenital long QT or significant cardiac disease.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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