Drug interactions
Chlorpromazine + Lisdexamfetamine
Severity: Moderate
Chlorpromazine and Lisdexamfetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine blocks dopamine receptors and can reduce the stimulant effect of amphetamine, while amphetamine may counter its sedation. Both can affect cardiac function, so arrhythmia risk may rise in predisposed patients.
What this interaction means in plain words
Chlorpromazine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Opposing dopaminergic effects with additive cardiovascular and QT effects.
What to do
Monitor clinical response, heart rate and blood pressure. Obtain an ECG if the patient has cardiac risk factors or takes other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Lisdexamfetamine?
MediHelp rates the interaction as moderate. Chlorpromazine and Lisdexamfetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine blocks dopamine receptors and can reduce the stimulant effect of amphetamine, while amphetamine may counter its sedation. Both can affect cardiac function, so arrhythmia risk may rise in predisposed patients.
How serious is the interaction between Chlorpromazine and Lisdexamfetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, heart rate and blood pressure. Obtain an ECG if the patient has cardiac risk factors or takes other QT-prolonging drugs.
What other medicines interact with Lisdexamfetamine?
MediHelp also lists interactions of Lisdexamfetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Lisdexamfetamine page.
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