Drug interactions
Chlorpromazine + Maraviroc
Severity: Minor
Chlorpromazine and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine is partly metabolized by CYP2D6, and maraviroc has been listed as a possible weak inhibitor of this enzyme. Any rise in chlorpromazine levels is likely small, though sedation, hypotension or extrapyramidal effects could increase in some patients.
What this interaction means in plain words
Chlorpromazine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpromazine belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Possible weak inhibition of CYP2D6-mediated chlorpromazine metabolism; clinical relevance is unproven.
What to do
No routine dose change is needed. Monitor for increased sedation, hypotension or extrapyramidal symptoms after starting maraviroc.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Chlorpromazine with Maraviroc?
MediHelp rates the interaction as minor. Chlorpromazine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpromazine is partly metabolized by CYP2D6, and maraviroc has been listed as a possible weak inhibitor of this enzyme. Any rise in chlorpromazine levels is likely small, though sedation, hypotension or extrapyramidal effects could increase in some patients.
How serious is the interaction between Chlorpromazine and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for increased sedation, hypotension or extrapyramidal symptoms after starting maraviroc.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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