Drug interactions
Chlorpromazine + Posaconazole
Severity: Major
Chlorpromazine and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combining them increases the risk of torsades de pointes and sudden cardiac death. The risk is higher with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
What this interaction means in plain words
Chlorpromazine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive prolongation of cardiac repolarisation (QT interval).
What to do
Check a baseline ECG and electrolytes, correct any deficits, and repeat the ECG after starting the combination. Use an alternative antifungal or antipsychotic if the QTc is markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Frequently asked questions
Can I take Chlorpromazine with Posaconazole?
MediHelp rates the interaction as major. Chlorpromazine and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combining them increases the risk of torsades de pointes and sudden cardiac death. The risk is higher with hypokalaemia, hypomagnesaemia, bradycardia or structural heart disease.
How serious is the interaction between Chlorpromazine and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, correct any deficits, and repeat the ECG after starting the combination. Use an alternative antifungal or antipsychotic if the QTc is markedly prolonged.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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