Drug interactions
Chlorpromazine + Propofol
Severity: Moderate
Chlorpromazine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpromazine enhances the sedative and hypotensive effects of propofol, which can deepen anesthesia and cause respiratory depression and low blood pressure.
What this interaction means in plain words
Chlorpromazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilation or alpha-blockade.
What to do
Titrate propofol carefully, usually with a lower dose, and monitor airway, ventilation and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Chlorpromazine with Propofol?
MediHelp rates the interaction as moderate. Chlorpromazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorpromazine enhances the sedative and hypotensive effects of propofol, which can deepen anesthesia and cause respiratory depression and low blood pressure.
How serious is the interaction between Chlorpromazine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol carefully, usually with a lower dose, and monitor airway, ventilation and blood pressure continuously.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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