Drug interactions
Cholecalciferol + Hydrochlorothiazide
Severity: Moderate
Cholecalciferol and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide reduces urinary calcium excretion and can add to the calcium-raising effect of vitamin D. Hypercalcemia may result, particularly with high doses or renal impairment.
What this interaction means in plain words
Cholecalciferol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholecalciferol belongs to Musculoskeletal; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides increase renal calcium reabsorption, adding to vitamin D-driven calcium absorption.
What to do
Monitor serum calcium periodically and lower the vitamin D dose if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Cholecalciferol with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cholecalciferol and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide reduces urinary calcium excretion and can add to the calcium-raising effect of vitamin D. Hypercalcemia may result, particularly with high doses or renal impairment.
How serious is the interaction between Cholecalciferol and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and lower the vitamin D dose if hypercalcemia develops.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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