Drug interactions
Cholecalciferol + Metolazone
Severity: Moderate
Cholecalciferol and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone, like other thiazide-type diuretics, reduces urinary calcium excretion. Combined with vitamin D supplementation, which increases intestinal calcium absorption, serum calcium may rise and occasionally cause hypercalcemia, especially with high vitamin D doses or renal impairment.
What this interaction means in plain words
Cholecalciferol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholecalciferol belongs to Musculoskeletal; Metolazone belongs to Cardiovascular.
Why it happens
Thiazide-type diuretics enhance distal tubular calcium reabsorption, which adds to the vitamin D-driven increase in calcium absorption.
What to do
Monitor serum calcium periodically, especially after starting or raising the vitamin D dose. Reduce or stop vitamin D if hypercalcemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Metolazone
Frequently asked questions
Can I take Cholecalciferol with Metolazone?
MediHelp rates the interaction as moderate. Cholecalciferol and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone, like other thiazide-type diuretics, reduces urinary calcium excretion. Combined with vitamin D supplementation, which increases intestinal calcium absorption, serum calcium may rise and occasionally cause hypercalcemia, especially with high vitamin D doses or renal impairment.
How serious is the interaction between Cholecalciferol and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically, especially after starting or raising the vitamin D dose. Reduce or stop vitamin D if hypercalcemia develops.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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