Drug interactions
Ciclesonide + Idelalisib
Severity: Moderate
Ciclesonide and Idelalisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may considerably increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
What this interaction means in plain words
Ciclesonide and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Idelalisib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition by idelalisib decreases ciclesonide clearance.
What to do
Monitor for Cushing's features and adrenal suppression during prolonged co-use. Consider an alternative inhaled corticosteroid if long-term therapy is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Ciclesonide with Idelalisib?
MediHelp rates the interaction as moderate. Ciclesonide and Idelalisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and may considerably increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
How serious is the interaction between Ciclesonide and Idelalisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushing's features and adrenal suppression during prolonged co-use. Consider an alternative inhaled corticosteroid if long-term therapy is required.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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