Drug interactions
Ciclesonide + Lopinavir
Severity: Moderate
Ciclesonide and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir, which is co-formulated with ritonavir, strongly inhibits CYP3A4 and can raise ciclesonide exposure. Cushing's syndrome and adrenal suppression are possible with chronic use.
What this interaction means in plain words
Ciclesonide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Lopinavir belongs to Anti Virals.
Why it happens
CYP3A4 inhibition by ritonavir-boosted lopinavir reduces ciclesonide metabolism.
What to do
Monitor for systemic corticosteroid effects with long-term therapy. Consider switching to beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ciclesonide with Lopinavir?
MediHelp rates the interaction as moderate. Ciclesonide and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir, which is co-formulated with ritonavir, strongly inhibits CYP3A4 and can raise ciclesonide exposure. Cushing's syndrome and adrenal suppression are possible with chronic use.
How serious is the interaction between Ciclesonide and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for systemic corticosteroid effects with long-term therapy. Consider switching to beclomethasone.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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