Drug interactions
Colesevelam + Ergocalciferol
Severity: Minor
Colesevelam and Ergocalciferol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Colesevelam may reduce absorption of fat-soluble vitamins, including vitamin D, though its effect is generally weaker than that of older resins. Prolonged use might lower vitamin D levels.
What this interaction means in plain words
Colesevelam and Ergocalciferol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Colesevelam belongs to Endocrine; Ergocalciferol belongs to Musculoskeletal.
Why it happens
Bile acid sequestration reduces intestinal absorption of fat-soluble vitamins.
What to do
Take vitamin D at least 4 hours before colesevelam. Check vitamin D status if long-term therapy is planned.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Moderate
- Amlodipine-olmesartan + Colesevelam Moderate
- Chenodiol + Colesevelam Moderate
- Cholic acid + Colesevelam Moderate
- Colesevelam + Cyclosporin Moderate
- Colesevelam + Glibenclamide Moderate
Frequently asked questions
Can I take Colesevelam with Ergocalciferol?
MediHelp rates the interaction as minor. Colesevelam and Ergocalciferol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Colesevelam may reduce absorption of fat-soluble vitamins, including vitamin D, though its effect is generally weaker than that of older resins. Prolonged use might lower vitamin D levels.
How serious is the interaction between Colesevelam and Ergocalciferol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 4 hours before colesevelam. Check vitamin D status if long-term therapy is planned.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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