Drug interactions
Crofelemer + Fenofibrate
Severity: Minor
Crofelemer and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. Fenofibrate is mainly cleared by esterase hydrolysis and glucuronidation rather than CYP3A4, so a meaningful change in exposure is not expected.
What this interaction means in plain words
Crofelemer and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Crofelemer belongs to Gastrointestinal Tract; Fenofibrate belongs to Cardiovascular.
Why it happens
Theoretical intestinal CYP3A4 inhibition by crofelemer; fenofibrate is not a major CYP3A4 substrate.
What to do
No specific action is needed beyond routine lipid monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporin + Fenofibrate Moderate
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Crofelemer with Fenofibrate?
MediHelp rates the interaction as minor. Crofelemer and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 in the gut, but it is minimally absorbed so systemic effects are unlikely. Fenofibrate is mainly cleared by esterase hydrolysis and glucuronidation rather than CYP3A4, so a meaningful change in exposure is not expected.
How serious is the interaction between Crofelemer and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine lipid monitoring.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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