Drug interactions
Danicopan + Mitomycin
Severity: Minor
Danicopan and Mitomycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and raises concentrations of P-gp substrates. If mitomycin is affected, systemic exposure and toxicity such as myelosuppression could increase, though clinical data are lacking.
What this interaction means in plain words
Danicopan and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Inhibition of intestinal and cellular P-glycoprotein efflux by danicopan.
What to do
Monitor blood counts and other mitomycin toxicities, and consider mitomycin dose reduction if toxicity emerges.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Mitomycin?
MediHelp rates the interaction as minor. Danicopan and Mitomycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and raises concentrations of P-gp substrates. If mitomycin is affected, systemic exposure and toxicity such as myelosuppression could increase, though clinical data are lacking.
How serious is the interaction between Danicopan and Mitomycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and other mitomycin toxicities, and consider mitomycin dose reduction if toxicity emerges.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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