Drug interactions
Dexmethylphenidate + Ergotamine
Severity: Moderate
Dexmethylphenidate and Ergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate is a sympathomimetic stimulant that can raise blood pressure and cause vasoconstriction. With ergotamine, additive vasoconstriction may lead to hypertension or peripheral ischemia.
What this interaction means in plain words
Dexmethylphenidate and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmethylphenidate belongs to Central Nervous System; Ergotamine belongs to Central Nervous System.
Why it happens
Additive vasoconstrictor and pressor effects.
What to do
Monitor blood pressure and peripheral circulation; prefer a non-ergot migraine treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Ergotamine?
MediHelp rates the interaction as moderate. Dexmethylphenidate and Ergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmethylphenidate is a sympathomimetic stimulant that can raise blood pressure and cause vasoconstriction. With ergotamine, additive vasoconstriction may lead to hypertension or peripheral ischemia.
How serious is the interaction between Dexmethylphenidate and Ergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and peripheral circulation; prefer a non-ergot migraine treatment.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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