Drug interactions
Digoxin + Dofetilide
Severity: Moderate
Digoxin and Dofetilide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are used for atrial arrhythmias and may be combined in practice. Digoxin does not clearly raise dofetilide levels, but the combination carries additive proarrhythmic risk, and hypokalemia from other causes heightens the danger.
What this interaction means in plain words
Digoxin and Dofetilide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Dofetilide belongs to Cardiovascular.
Why it happens
Dofetilide prolongs repolarization while digoxin adds arrhythmogenic effects; renal cationic competition is a minor pharmacokinetic contributor.
What to do
Initiate dofetilide in a monitored setting with ECG QTc monitoring and renal function checks. Keep potassium and magnesium within normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Digoxin with Dofetilide?
MediHelp rates the interaction as moderate. Digoxin and Dofetilide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are used for atrial arrhythmias and may be combined in practice. Digoxin does not clearly raise dofetilide levels, but the combination carries additive proarrhythmic risk, and hypokalemia from other causes heightens the danger.
How serious is the interaction between Digoxin and Dofetilide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Initiate dofetilide in a monitored setting with ECG QTc monitoring and renal function checks. Keep potassium and magnesium within normal range.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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