Drug interactions
Disopyramide + Enzalutamide
Severity: Moderate
Disopyramide and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide may lower disopyramide levels by inducing its CYP3A4-mediated metabolism, and antiarrhythmic control may be lost. The metabolism to the less active but more anticholinergic metabolite may increase.
What this interaction means in plain words
Disopyramide and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Enzalutamide belongs to Endocrine.
Why it happens
CYP3A4 induction by enzalutamide increases disopyramide clearance.
What to do
Monitor ECG and arrhythmia control and check disopyramide concentrations where available, adjusting the dose as needed. Watch for anticholinergic effects from the metabolite.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Enzalutamide?
MediHelp rates the interaction as moderate. Disopyramide and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide may lower disopyramide levels by inducing its CYP3A4-mediated metabolism, and antiarrhythmic control may be lost. The metabolism to the less active but more anticholinergic metabolite may increase.
How serious is the interaction between Disopyramide and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and arrhythmia control and check disopyramide concentrations where available, adjusting the dose as needed. Watch for anticholinergic effects from the metabolite.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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