Drug interactions
Disopyramide + Secukinumab
Severity: Minor
Disopyramide and Secukinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secukinumab may normalize CYP enzyme expression suppressed by chronic inflammation, which could change clearance of CYP3A4 substrates. Disopyramide has a narrow therapeutic index, so altered levels could affect arrhythmia control. The effect is theoretical.
What this interaction means in plain words
Disopyramide and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Disopyramide belongs to Cardiovascular; Secukinumab belongs to Miscellaneous.
Why it happens
Normalization of cytokine-suppressed CYP450 expression after IL-17A blockade, potentially increasing disopyramide metabolism.
What to do
Monitor ECG and antiarrhythmic response when secukinumab is started or stopped. Adjust the disopyramide dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Secukinumab
- Adenovirus types 4 and 7 live + Secukinumab Major
- Bcg vaccine live + Secukinumab Major
- Influenza virus vaccine quadrivalent intranasal + Secukinumab Major
- Measles mumps and rubella vaccine live + Secukinumab Major
- Measles mumps and rubella vaccine + Secukinumab Major
- Measles mumps rubella and varicella vaccine live + Secukinumab Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Secukinumab?
MediHelp rates the interaction as minor. Disopyramide and Secukinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Secukinumab may normalize CYP enzyme expression suppressed by chronic inflammation, which could change clearance of CYP3A4 substrates. Disopyramide has a narrow therapeutic index, so altered levels could affect arrhythmia control. The effect is theoretical.
How serious is the interaction between Disopyramide and Secukinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and antiarrhythmic response when secukinumab is started or stopped. Adjust the disopyramide dose as needed.
What other medicines interact with Secukinumab?
MediHelp also lists interactions of Secukinumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Secukinumab page.
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