Drug interactions
Dofetilide + Indacaterol
Severity: Major
Dofetilide and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a dose-related risk of torsades de pointes. Indacaterol can add QT effects and lower potassium, which increases proarrhythmic risk. Dofetilide is started under continuous ECG monitoring because of this risk.
What this interaction means in plain words
Dofetilide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive QT prolongation with hypokalemia as a potentiating factor.
What to do
Avoid the combination where possible; if needed, monitor ECG and keep potassium and magnesium normal, and reduce or stop dofetilide if QTc increases.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Indacaterol?
MediHelp rates the interaction as major. Dofetilide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide has a dose-related risk of torsades de pointes. Indacaterol can add QT effects and lower potassium, which increases proarrhythmic risk. Dofetilide is started under continuous ECG monitoring because of this risk.
How serious is the interaction between Dofetilide and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if needed, monitor ECG and keep potassium and magnesium normal, and reduce or stop dofetilide if QTc increases.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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