Drug interactions
Duloxetine + Rolapitant
Severity: Moderate
Duloxetine and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duloxetine is cleared by CYP2D6 and CYP1A2, and rolapitant inhibits CYP2D6 for a prolonged period. Duloxetine levels may increase, leading to more nausea, dizziness, blood pressure elevation or serotonergic effects.
What this interaction means in plain words
Duloxetine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Duloxetine belongs to Central Nervous System; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, reducing the metabolism of duloxetine.
What to do
Monitor for adverse effects of duloxetine, including blood pressure and serotonergic symptoms. Lower the dose if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Frequently asked questions
Can I take Duloxetine with Rolapitant?
MediHelp rates the interaction as moderate. Duloxetine and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duloxetine is cleared by CYP2D6 and CYP1A2, and rolapitant inhibits CYP2D6 for a prolonged period. Duloxetine levels may increase, leading to more nausea, dizziness, blood pressure elevation or serotonergic effects.
How serious is the interaction between Duloxetine and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of duloxetine, including blood pressure and serotonergic symptoms. Lower the dose if tolerability worsens.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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