Drug interactions
Dutasteride + Posaconazole
Severity: Minor
Dutasteride and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a strong CYP3A4 inhibitor and may raise dutasteride exposure. Because dutasteride is well tolerated at higher exposures, the effect is usually of limited concern.
What this interaction means in plain words
Dutasteride and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dutasteride belongs to Genitourinary; Posaconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition by posaconazole reduces dutasteride clearance.
What to do
No dose change is generally required; monitor for dutasteride adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride
- Dutasteride + Levoketoconazole Moderate
- Dutasteride + Nefazodone Moderate
- Dutasteride + Rifampin Moderate
- Dutasteride + St john's wort Moderate
- Amobarbital + Dutasteride Minor
- Aprepitant + Dutasteride Minor
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dutasteride with Posaconazole?
MediHelp rates the interaction as minor. Dutasteride and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Posaconazole is a strong CYP3A4 inhibitor and may raise dutasteride exposure. Because dutasteride is well tolerated at higher exposures, the effect is usually of limited concern.
How serious is the interaction between Dutasteride and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required; monitor for dutasteride adverse effects during prolonged co-therapy.
What other medicines interact with Dutasteride?
MediHelp also lists interactions of Dutasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Dutasteride page.
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