Drug interactions
Elagolix + Enzalutamide
Severity: Moderate
Elagolix and Enzalutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A4 inducer, may reduce elagolix exposure and its efficacy for endometriosis or fibroid symptoms. Elagolix is itself a weak-to-moderate CYP3A4 inducer, so enzalutamide levels could fall slightly, though this is of uncertain significance.
What this interaction means in plain words
Elagolix and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Enzalutamide belongs to Endocrine.
Why it happens
Mutual CYP3A4 induction, with enzalutamide's strong induction dominating and lowering elagolix concentrations.
What to do
Monitor for reduced symptom control with elagolix and consider whether the combination is needed. Monitor for reduced enzalutamide response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Enzalutamide?
MediHelp rates the interaction as moderate. Elagolix and Enzalutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide, a strong CYP3A4 inducer, may reduce elagolix exposure and its efficacy for endometriosis or fibroid symptoms. Elagolix is itself a weak-to-moderate CYP3A4 inducer, so enzalutamide levels could fall slightly, though this is of uncertain significance.
How serious is the interaction between Elagolix and Enzalutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced symptom control with elagolix and consider whether the combination is needed. Monitor for reduced enzalutamide response.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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