Drug interactions
Elagolix + Ivermectin
Severity: Minor
Elagolix and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix can inhibit intestinal P-glycoprotein and may modestly increase ivermectin concentrations. The effect is likely small and clinically unimportant at normal ivermectin doses.
What this interaction means in plain words
Elagolix and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Ivermectin belongs to Anti Parasitic.
Why it happens
Elagolix inhibits P-glycoprotein efflux of ivermectin.
What to do
No dose adjustment is usually needed. Be alert for neurologic or gastrointestinal adverse effects with prolonged ivermectin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Ivermectin?
MediHelp rates the interaction as minor. Elagolix and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix can inhibit intestinal P-glycoprotein and may modestly increase ivermectin concentrations. The effect is likely small and clinically unimportant at normal ivermectin doses.
How serious is the interaction between Elagolix and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be alert for neurologic or gastrointestinal adverse effects with prolonged ivermectin use.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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