Drug interactions
Elagolix + Posaconazole
Severity: Moderate
Elagolix and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises elagolix exposure through CYP3A inhibition, which increases the risk of dose-related effects such as bone mineral density loss and liver enzyme elevation. Elagolix may also inhibit P-gp and modestly increase posaconazole levels.
What this interaction means in plain words
Elagolix and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elagolix belongs to Musculoskeletal; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A-mediated elagolix metabolism, while elagolix may weakly inhibit P-gp efflux of posaconazole.
What to do
Limit elagolix to 150 mg once daily for no more than 6 months with strong CYP3A inhibitors, and avoid the 200 mg twice-daily regimen beyond one month. Monitor liver tests and bone health.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Posaconazole?
MediHelp rates the interaction as moderate. Elagolix and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises elagolix exposure through CYP3A inhibition, which increases the risk of dose-related effects such as bone mineral density loss and liver enzyme elevation. Elagolix may also inhibit P-gp and modestly increase posaconazole levels.
How serious is the interaction between Elagolix and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit elagolix to 150 mg once daily for no more than 6 months with strong CYP3A inhibitors, and avoid the 200 mg twice-daily regimen beyond one month. Monitor liver tests and bone health.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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