Drug interactions
Elagolix + Progesterone
Severity: Minor
Elagolix and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a CYP3A4 inducer and weak CYP2C19 inhibitor, so its net effect on progesterone is uncertain but a reduction in exposure is more likely. Elagolix also suppresses ovarian hormones, and combining it with progestogens is not a standard approach outside add-back regimens.
What this interaction means in plain words
Elagolix and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elagolix belongs to Musculoskeletal; Progesterone belongs to Endocrine.
Why it happens
Mixed CYP3A4 induction and CYP2C19 inhibition by elagolix alters progesterone metabolism.
What to do
Monitor for reduced progestogenic effect and adjust the dose if clinically needed. Do not rely on progesterone for contraception during elagolix use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Elagolix and Progesterone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Progesterone
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Elagolix with Progesterone?
MediHelp rates the interaction as minor. Elagolix and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a CYP3A4 inducer and weak CYP2C19 inhibitor, so its net effect on progesterone is uncertain but a reduction in exposure is more likely. Elagolix also suppresses ovarian hormones, and combining it with progestogens is not a standard approach outside add-back regimens.
How serious is the interaction between Elagolix and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestogenic effect and adjust the dose if clinically needed. Do not rely on progesterone for contraception during elagolix use.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
