Drug interactions
Empagliflozin + Furosemide
Severity: Moderate
Empagliflozin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Empagliflozin causes osmotic diuresis and mild natriuresis, which adds to furosemide's effect and can cause volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
What this interaction means in plain words
Empagliflozin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Empagliflozin belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic diuresis from SGLT2 inhibition and loop diuretic action.
What to do
Assess volume status before starting empagliflozin and consider reducing the furosemide dose in patients at risk. Monitor blood pressure, weight and renal function after initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Frequently asked questions
Can I take Empagliflozin with Furosemide?
MediHelp rates the interaction as moderate. Empagliflozin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Empagliflozin causes osmotic diuresis and mild natriuresis, which adds to furosemide's effect and can cause volume depletion, hypotension and acute kidney injury, particularly in older or frail patients.
How serious is the interaction between Empagliflozin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting empagliflozin and consider reducing the furosemide dose in patients at risk. Monitor blood pressure, weight and renal function after initiation.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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