Drug interactions
Empagliflozin + Letermovir
Severity: Minor
Empagliflozin and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may modestly raise empagliflozin exposure, possibly through inhibition of hepatic uptake or glucuronidation pathways. The clinical effect is expected to be small, as empagliflozin has a wide therapeutic margin.
What this interaction means in plain words
Empagliflozin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Empagliflozin belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Possible inhibition of OATP1B1/3 or UGT-mediated clearance of empagliflozin by letermovir; not firmly established.
What to do
No dose change is usually needed. Monitor glucose and volume status as per routine care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Empagliflozin
- Amiloride + Empagliflozin Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Empagliflozin Moderate
- Amlodipine-olmesartan-hydrochlorothiazide + Empagliflozin Moderate
- Atenolol-chlorthalidone + Empagliflozin Moderate
- Azilsartan-chlorthalidone + Empagliflozin Moderate
- Bendroflumethiazide + Empagliflozin Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Empagliflozin with Letermovir?
MediHelp rates the interaction as minor. Empagliflozin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may modestly raise empagliflozin exposure, possibly through inhibition of hepatic uptake or glucuronidation pathways. The clinical effect is expected to be small, as empagliflozin has a wide therapeutic margin.
How serious is the interaction between Empagliflozin and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor glucose and volume status as per routine care.
What other medicines interact with Empagliflozin?
MediHelp also lists interactions of Empagliflozin with, for example, Amiloride, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Empagliflozin page.
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