Drug interactions
Enfortumab vedotin + Enzalutamide
Severity: Minor
Enfortumab vedotin and Enzalutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The cytotoxic payload of enfortumab vedotin, MMAE, is metabolized by CYP3A4, and enzalutamide could lower free MMAE exposure. The clinical effect is probably small and might slightly reduce antitumor activity.
What this interaction means in plain words
Enfortumab vedotin and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enfortumab vedotin belongs to Oncology; Enzalutamide belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, potentially increasing clearance of unconjugated MMAE.
What to do
No dose change is usually needed; monitor clinical response to enfortumab vedotin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Enfortumab vedotin
- Chloramphenicol + Enfortumab vedotin Moderate
- Clarithromycin + Enfortumab vedotin Moderate
- Enfortumab vedotin + Isoniazid Moderate
- Enfortumab vedotin + Itraconazole Moderate
- Enfortumab vedotin + Ketoconazole Moderate
- Enfortumab vedotin + Mifepristone Moderate
Frequently asked questions
Can I take Enfortumab vedotin with Enzalutamide?
MediHelp rates the interaction as minor. Enfortumab vedotin and Enzalutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The cytotoxic payload of enfortumab vedotin, MMAE, is metabolized by CYP3A4, and enzalutamide could lower free MMAE exposure. The clinical effect is probably small and might slightly reduce antitumor activity.
How serious is the interaction between Enfortumab vedotin and Enzalutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; monitor clinical response to enfortumab vedotin.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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