Drug interactions
Enzalutamide + Medroxyprogesterone
Severity: Moderate
Enzalutamide and Medroxyprogesterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide, a strong CYP3A4 inducer, may lower medroxyprogesterone concentrations. This could reduce contraceptive or therapeutic progestin effect, leading to contraceptive failure or loss of endometrial protection.
What this interaction means in plain words
Enzalutamide and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Medroxyprogesterone belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, which increases medroxyprogesterone metabolism.
What to do
Use a non-hormonal or additional barrier contraceptive method if contraception is required. Monitor for loss of therapeutic effect when used for other indications.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Medroxyprogesterone
Frequently asked questions
Can I take Enzalutamide with Medroxyprogesterone?
MediHelp rates the interaction as moderate. Enzalutamide and Medroxyprogesterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide, a strong CYP3A4 inducer, may lower medroxyprogesterone concentrations. This could reduce contraceptive or therapeutic progestin effect, leading to contraceptive failure or loss of endometrial protection.
How serious is the interaction between Enzalutamide and Medroxyprogesterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal or additional barrier contraceptive method if contraception is required. Monitor for loss of therapeutic effect when used for other indications.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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