Drug interactions
Enzalutamide + Posaconazole
Severity: Moderate
Enzalutamide and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is metabolized partly by CYP3A4 and CYP2C8, so posaconazole may increase concentrations of enzalutamide and its active metabolite, raising seizure and other adverse-effect risk. However enzalutamide is a strong CYP3A4 inducer and can reduce posaconazole exposure, potentially compromising antifungal efficacy.
What this interaction means in plain words
Enzalutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of enzalutamide, while enzalutamide induces CYP3A4 and UGT, lowering posaconazole levels.
What to do
Monitor for enzalutamide toxicity such as seizures and fatigue, and monitor posaconazole trough levels or antifungal response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Posaconazole?
MediHelp rates the interaction as moderate. Enzalutamide and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Enzalutamide is metabolized partly by CYP3A4 and CYP2C8, so posaconazole may increase concentrations of enzalutamide and its active metabolite, raising seizure and other adverse-effect risk. However enzalutamide is a strong CYP3A4 inducer and can reduce posaconazole exposure, potentially compromising antifungal efficacy.
How serious is the interaction between Enzalutamide and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for enzalutamide toxicity such as seizures and fatigue, and monitor posaconazole trough levels or antifungal response.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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