Drug interactions
Enzalutamide + Teriflunomide
Severity: Minor
Enzalutamide and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide inhibits CYP2C8, which is a main pathway for enzalutamide metabolism to its active metabolite. Exposure could rise somewhat, but the effect on active moiety is likely modest.
What this interaction means in plain words
Enzalutamide and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Enzalutamide belongs to Endocrine; Teriflunomide belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C8 by teriflunomide may reduce enzalutamide clearance.
What to do
No routine adjustment; watch for enzalutamide adverse effects such as fatigue, seizures or hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Teriflunomide
Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Frequently asked questions
Can I take Enzalutamide with Teriflunomide?
MediHelp rates the interaction as minor. Enzalutamide and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide inhibits CYP2C8, which is a main pathway for enzalutamide metabolism to its active metabolite. Exposure could rise somewhat, but the effect on active moiety is likely modest.
How serious is the interaction between Enzalutamide and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; watch for enzalutamide adverse effects such as fatigue, seizures or hypertension.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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