Drug interactions
Enzalutamide + Toremifene
Severity: Moderate
Enzalutamide and Toremifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Toremifene is cleared by CYP3A4, and strong inducers reduce its concentrations. Enzalutamide may lower toremifene efficacy, though QT risk from toremifene itself is reduced.
What this interaction means in plain words
Enzalutamide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Enzalutamide belongs to Endocrine; Toremifene belongs to Endocrine.
Why it happens
Enzalutamide induces CYP3A4, accelerating toremifene metabolism.
What to do
Monitor clinical response to toremifene; a doubled toremifene dose may be needed per labeling for strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Toremifene
- Amiodarone + Toremifene Contraindicated
- Dronedarone + Toremifene Contraindicated
- Nilotinib + Toremifene Contraindicated
- Pimozide + Toremifene Contraindicated
- Quinidine + Toremifene Contraindicated
- Ribociclib + Toremifene Contraindicated
Frequently asked questions
Can I take Enzalutamide with Toremifene?
MediHelp rates the interaction as moderate. Enzalutamide and Toremifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Toremifene is cleared by CYP3A4, and strong inducers reduce its concentrations. Enzalutamide may lower toremifene efficacy, though QT risk from toremifene itself is reduced.
How serious is the interaction between Enzalutamide and Toremifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to toremifene; a doubled toremifene dose may be needed per labeling for strong inducers.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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