Drug interactions
Enzalutamide + Tucatinib
Severity: Major
Enzalutamide and Tucatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Enzalutamide is expected to reduce tucatinib exposure through CYP3A4 induction, while tucatinib may increase enzalutamide levels through CYP3A inhibition. The net effect is reduced tucatinib efficacy and possible enzalutamide toxicity such as seizures.
What this interaction means in plain words
Enzalutamide and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Enzalutamide belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Enzalutamide induces CYP3A4 lowering tucatinib; tucatinib inhibits CYP3A raising enzalutamide.
What to do
Avoid concomitant use. If unavoidable, monitor for loss of tucatinib efficacy and enzalutamide adverse effects, reducing the enzalutamide dose as labeling recommends.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Enzalutamide
- Doravirine + Enzalutamide Contraindicated
- Elbasvir / grazoprevir + Enzalutamide Contraindicated
- Ensitrelvir + Enzalutamide Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Enzalutamide with Tucatinib?
MediHelp rates the interaction as major. Enzalutamide and Tucatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is expected to reduce tucatinib exposure through CYP3A4 induction, while tucatinib may increase enzalutamide levels through CYP3A inhibition. The net effect is reduced tucatinib efficacy and possible enzalutamide toxicity such as seizures.
How serious is the interaction between Enzalutamide and Tucatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. If unavoidable, monitor for loss of tucatinib efficacy and enzalutamide adverse effects, reducing the enzalutamide dose as labeling recommends.
What other medicines interact with Enzalutamide?
MediHelp also lists interactions of Enzalutamide with, for example, Doravirine, Elbasvir / grazoprevir, Ensitrelvir. The full list is on the Enzalutamide page.
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