Drug interactions
Ergocalciferol + Sucralfate
Severity: Moderate
Ergocalciferol and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate contains aluminum, and a small fraction is normally absorbed. Vitamin D increases intestinal absorption of aluminum, which may raise aluminum accumulation, especially in patients with reduced kidney function.
What this interaction means in plain words
Ergocalciferol and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ergocalciferol belongs to Musculoskeletal; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Vitamin D enhances intestinal absorption of aluminum released from sucralfate.
What to do
Avoid long-term coadministration in patients with renal impairment and consider an alternative to sucralfate. If used together, monitor for signs of aluminum toxicity such as bone disease or neurotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ergocalciferol and Sucralfate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Sucralfate
Frequently asked questions
Can I take Ergocalciferol with Sucralfate?
MediHelp rates the interaction as moderate. Ergocalciferol and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate contains aluminum, and a small fraction is normally absorbed. Vitamin D increases intestinal absorption of aluminum, which may raise aluminum accumulation, especially in patients with reduced kidney function.
How serious is the interaction between Ergocalciferol and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term coadministration in patients with renal impairment and consider an alternative to sucralfate. If used together, monitor for signs of aluminum toxicity such as bone disease or neurotoxicity.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
