Drug interactions
Ertugliflozin-sitagliptin + Fostamatinib
Severity: Minor
Ertugliflozin-sitagliptin and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may increase sitagliptin exposure. Given sitagliptin's wide margin, the clinical effect is expected to be small.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ertugliflozin-sitagliptin belongs to Endocrine; Fostamatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of sitagliptin by the fostamatinib metabolite tamatinib.
What to do
No empiric dose change needed. Monitor for sitagliptin adverse effects and glycemic response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Fostamatinib?
MediHelp rates the interaction as minor. Ertugliflozin-sitagliptin and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and may increase sitagliptin exposure. Given sitagliptin's wide margin, the clinical effect is expected to be small.
How serious is the interaction between Ertugliflozin-sitagliptin and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change needed. Monitor for sitagliptin adverse effects and glycemic response.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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