Drug interactions
Ertugliflozin-sitagliptin + Hydrochlorothiazide
Severity: Moderate
Ertugliflozin-sitagliptin and Hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can raise blood glucose and may reduce glycemic control. Combined diuretic effects with ertugliflozin can add to volume depletion and hypotension.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides impair insulin secretion and sensitivity via hypokalemia, and ertugliflozin adds osmotic diuresis.
What to do
Monitor blood glucose, blood pressure, renal function and electrolytes. Adjust diuretic or antidiabetic doses if volume depletion or hyperglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Hydrochlorothiazide
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Hydrochlorothiazide?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can raise blood glucose and may reduce glycemic control. Combined diuretic effects with ertugliflozin can add to volume depletion and hypotension.
How serious is the interaction between Ertugliflozin-sitagliptin and Hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, blood pressure, renal function and electrolytes. Adjust diuretic or antidiabetic doses if volume depletion or hyperglycemia occurs.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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