Drug interactions
Ertugliflozin-sitagliptin + Lopinavir
Severity: Moderate
Ertugliflozin-sitagliptin and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Glycemic control may worsen in patients with diabetes.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Lopinavir belongs to Anti Virals.
Why it happens
Protease inhibitor associated insulin resistance and impaired glucose metabolism oppose the glucose-lowering drugs.
What to do
Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen, and intensify antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Lopinavir?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as lopinavir/ritonavir can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Glycemic control may worsen in patients with diabetes.
How serious is the interaction between Ertugliflozin-sitagliptin and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the antiretroviral regimen, and intensify antidiabetic therapy if needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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