Drug interactions
Ertugliflozin-sitagliptin + Metolazone
Severity: Moderate
Ertugliflozin-sitagliptin and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metolazone can raise blood glucose and, with ertugliflozin, add to diuresis, volume depletion and electrolyte loss. This may worsen glycemic control and renal perfusion.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Metolazone belongs to Cardiovascular.
Why it happens
Thiazide-like diuretic effects on insulin secretion and potassium, plus additive osmotic and natriuretic effects with ertugliflozin.
What to do
Monitor blood glucose, volume status, renal function and electrolytes. Reduce diuretic dose or adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Metolazone
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Metolazone?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metolazone can raise blood glucose and, with ertugliflozin, add to diuresis, volume depletion and electrolyte loss. This may worsen glycemic control and renal perfusion.
How serious is the interaction between Ertugliflozin-sitagliptin and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, volume status, renal function and electrolytes. Reduce diuretic dose or adjust antidiabetic therapy if needed.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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