Drug interactions
Ertugliflozin-sitagliptin + Risperidone
Severity: Moderate
Ertugliflozin-sitagliptin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Risperidone can cause hyperglycemia and weight gain, which may reduce the effectiveness of antidiabetic therapy.
What this interaction means in plain words
Ertugliflozin-sitagliptin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ertugliflozin-sitagliptin belongs to Endocrine; Risperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related insulin resistance and impaired glucose regulation.
What to do
Monitor glucose and HbA1c after starting risperidone and adjust antidiabetic doses if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Ertugliflozin-sitagliptin with Risperidone?
MediHelp rates the interaction as moderate. Ertugliflozin-sitagliptin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Risperidone can cause hyperglycemia and weight gain, which may reduce the effectiveness of antidiabetic therapy.
How serious is the interaction between Ertugliflozin-sitagliptin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c after starting risperidone and adjust antidiabetic doses if control deteriorates.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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