Drug interactions
Estradiol + Givosiran
Severity: Minor
Estradiol and Givosiran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can inhibit CYP1A2 and may modestly raise estradiol levels, since CYP1A2 contributes to estradiol hydroxylation. The clinical effect is expected to be small.
What this interaction means in plain words
Estradiol and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Estradiol belongs to Endocrine; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran reduces CYP1A2 activity, slowing part of estradiol metabolism.
What to do
No routine adjustment is needed; watch for estrogenic adverse effects and reduce the estradiol dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Estradiol with Givosiran?
MediHelp rates the interaction as minor. Estradiol and Givosiran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Givosiran can inhibit CYP1A2 and may modestly raise estradiol levels, since CYP1A2 contributes to estradiol hydroxylation. The clinical effect is expected to be small.
How serious is the interaction between Estradiol and Givosiran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for estrogenic adverse effects and reduce the estradiol dose if they occur.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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