Drug interactions
Fedratinib + Fenofibrate
Severity: Minor
Fedratinib and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib inhibits CYP3A4, but fenofibrate is not mainly cleared by this pathway, so a clinically important increase in fenofibrate exposure is unlikely.
What this interaction means in plain words
Fedratinib and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Fedratinib belongs to Oncology; Fenofibrate belongs to Cardiovascular.
Why it happens
Theoretical CYP3A4 inhibition by fedratinib; fenofibric acid is cleared mainly by glucuronidation.
What to do
No dose adjustment is needed. Monitor for fenofibrate adverse effects as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fedratinib and Fenofibrate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Fedratinib with Fenofibrate?
MediHelp rates the interaction as minor. Fedratinib and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fedratinib inhibits CYP3A4, but fenofibrate is not mainly cleared by this pathway, so a clinically important increase in fenofibrate exposure is unlikely.
How serious is the interaction between Fedratinib and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for fenofibrate adverse effects as usual.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
